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Table 1 TNF-α release in C. pneumoniae infected type II cells

From: Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes

  Type II cells + C. pneumoniae Macrophages + C. pneumoniae Type II cells – 10% macrophages
0 min 7 ± 1 13.7 ± 2.7 5.6
30 min 21 ± 7.5 69.5 ± 11.3 14
1 hour 109 ± 22 174 ± 9 92
2 hours 183 ± 29 303 ± 69 153
3 hours 656* ± 103 661§ ± 41 590
6 hours 1006** ± 74 1070§S ± 58 899
12 hours 996 ± 294 1038 ± 207 893
  1. Mean values are given in pg/ml ± SD of three independent experiments.
  2. * P < 0.0001 vs. 0–2 and 6–12 hours + C. pneumoniae
  3. ** P < 0.0001 vs. 0–3 hours + C. pneumoniae
  4. § P < 0.0001 vs. 0–2 and 6–12 hours + C. pneumoniae
  5. §§ P < 0.0001 vs. 0–3 hours + C. pneumoniae