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Figure 3 | Respiratory Research

Figure 3

From: Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting

Figure 3

Antigens that elicit Th2 type response, but not Th1 type response, induce transfer-mediated AHR. (A) Antigens that elicit Th2 type response induce transfer-mediated AHR. Recipients received spleen cells (5 × 107) from SA (without alum)-treated mice (TRSA), from OVA-sensitized mice (TROVA), from SA (with alum)-treated mice (TRAlum), from BSA-sensitized mice (TRBSA), or from KLH-sensitized mice (TRKLH). AR was measured 4 days after the transfer (n = 4–9 per group). * p < 0.05 compared with PC200Mch of TRSA. (B) CFA, an adjuvant that elicits Th1 type response, does not induce transfer-mediated AHR. Recipients received spleen cells (5 × 107) from SA-treated mice (TRSA), from OVA (with alum)-sensitized mice (TROVA/Alum), from OVA (with CFA)-sensitized mice (TROVA/CFA), or from CFA-treated mice (TRCFA). AR was measured 4 days after the transfer (n = 4–9 per group). * p < 0.05 compared with PC200Mch of TRSA.

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