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Table 5 Mean annual change in FEV1 per pack-year to 1991 and per pack of cigarettes smoked per day between 1991 and 2002 by degree of airway obstruction in 1991

From: Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study

 

Term

Annual change in mL per pack-year to 1991

Annual change in mL per packs per day between 1991 and 2002

  

Coef

95%CI

p value

Coef

95%CI

p value

FEV1/FVC>0.7†

       

Men (n = 692)

Linear

-0.1

-0.3, 0.1

0.48

-8.8

-14.1, -3.5

0.001

   Women (n = 659)

Linear

1.4

0.8, 2.0

<0.001

-12.2

-18.1, -6.4

<0.001

 

Quadratic

-0.04

-0.06, -0.03

<0.001

na

na

na

 

Cubic

0.0004

0.0002, 0.0005

<0.001

na

na

na

FEV1/FVC<0.7†

       

Men (n = 127)

Linear

-0.2

-0.6, 0.2

0.36

-12.9

-25.0, -0.7

0.04

   Women (n = 67)

Linear

-0.9

-2.2, 0.5

0.21

-39.4

-69.1, -9.6

0.01

 

Quadratic

0.02

0.01, 0.04

0.009

na

na

na

  1. † P values for interaction between high and reduced FEV1/FVC with packs per day: men = 0.07 women = 0.002
  2. na: no association with polynomial terms
  3. Effects estimated from regression models with same covariates as in Table 3