# Table 3 Mean annual change in lung function per pack-year to 1991 and per pack of cigarettes smoked per day between 1991 and 2002 in women and men

Term Annual change per pack-year to 1991 Annual change per packs per day between 1991 and 2002
Coef 95%CI p value Coef 95%CI p value
FEV1[mL]
Men (n = 840) Linear -0.1 -0.2, 0.1 0.50 -10.4 -15.3, -5.5 <0.001
Women (n = 735) Linear 1.3 0.7, 2.0 <0.001 -13.8 -19.5, -8.1 <0.001
Quadratic -0.04 -0.06, -0.02 <0.001 na na na
Cubic 0.0004 0.0002, 0.0005 <0.001 na na na
FEF75[mL/s]
Men (n = 798) Linear -0.6 -1.4, 0.1 0.11 -35.1 -57.5, -12.7 0.002
Women (n = 697) Linear -0.2 -1.0, 0.7 0.64 -18.6 -42.7,4.9 0.12
FEF50[mL/s]
Men (n = 825) Linear -0.2 -0.6, 0.2 0.31 -22.4 -34.5, -10.3 <0.001
Women (n = 697) Linear 0.2 -0.3, 0.8 0.31 -31.3 -46.1, -16.5 <0.001
FEF25[mL/s]
Men (n = 823) Linear -0.05 -0.1, 0.1 0.59 -8.9 -14.5, -3.4 <0.002
Women (n = 731) Linear 1.1 0.2, 1.9 0.01 -10.0 -17.3, -2.8 0.007
Quadratic -0.03 -0.6, -0.01 0.01 na na na
Cubic 0.0003 0.00005, 0.0005 0.006 na na na
1. na: no association with polynomial terms
2. Covariates other than smoking variables:
3. Models for Men:
4. FEV1 FEV1, FEV1 2, age, height, atopy, weight change, current exposure to dust & fumes at work, study area
5. FEF75 FEF75, FEF75 2, age, age2, atopy, maternal smoking, study area
6. FEF50 FEF50, age, weight, study area
7. FEF25 FEF25, FEF25 2, FEF25 3, age, weight, weight change, study area
8. Models for Women:
9. FEV1 FEV1, FEV1 2, age, age2, height, height2, atopy, weight change, study area
10. FEF75 FEF75, FEF75 2, FEF75 3 age, paternal smoking, study area
11. FEF50 FEF50, age, weight, weight change, paternal smoking, study area
12. FEF25 FEF25, age, age2, height, weight, weight change, study area