Skip to main content

Advertisement

Table 1 Sputum inflammation in smokers with COPD, symptomatic smokers and asymptomatic smokers

From: Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers

  COPD Symptomatic smokers Asymptomatic smokers
  GOLD I-III GOLD 0  
Sputum, n 25 9 24
   Volume, ml 4.1 (0.7–14.3) 3.1 (0.3–10.0) 2.3 (0.6–10.8)*
   Total cells, 106 6.7 (1.4–54.5) 4.1 (1.1–15.3) 3.5 (0.2–23)*
   Cell conc., 103/ml 1507 (484–9620) 2134 (534–4146) 1445 (303–4592)
   Nonsquamous cells, % 94 (75–99.7) 92 (81–96) 88 (64–99.5)
   Eosinophils, 103/ml 15 (0–106) 20 (0–135) 13 (0–235)
   % 1.4 (0–4.0) 1.8 (0–4.1) 0.8 (0–12.6)
   Neutrophils, 103/ml  870 (235–7608) 1575 (434–2558) 661 (164–2856)
   % 72.6 (45–89) 66 (39–81) 60.1 (31.5–92.6)* †
   Macrophages, 103/ml 407 (89–2615) 535 (89–2422) 568 (22–1488)
   % 25.4 (8.2–52.7) 28.7 (16.6–58.4) 36 (6.5–62.4)*
   Lymphocytes, 103/ml  14 (0–77) 15 (0–62) 11 (1–161)
   % 0.8 (0.1–4) 0.8 (0.4–1.6) 0.7 (0.1–3.8)
   Epithelial cells, 103/ml  10 (0–107) 0.4 (0–84) 10 (0–55)
   % 0.5 (0–11) 0.5 (0–2.5) 0.8 (0–6.6)
   Basophils, 103/ml 0 (0–4) 0 (0–12) 0 (0–8)
   % 0 (0–0.1) 0 (0–0.3) 0 (0–0.3)
   IL-8, ng/ml 16.8 (2.1–161)† 8.7 (0.1–25.7) 5.3 (0–25)*
   ECP, μg/L 157 (32–2700) 119.8 (13.3–238) 66 (4.7–1282)*
  1. Values expressed in median (range). Abbreviations: cell conc. = cell concentration; IL-8 = interleukin-8; ECP = eosinophilic cationic protein.
  2. * p < 0.05 asymptomatic smokers versus total COPD (I-III), Mann-Whitney -U test, † p < 0.05 versus GOLD stage 0, Mann-Whitney-U test.