| |
COPD
|
Symptomatic smokers
|
Asymptomatic smokers
|
|---|
| |
GOLD I-III
|
GOLD 0
| |
|---|
|
Sputum, n
|
25
|
9
|
24
|
|
Volume, ml
|
4.1 (0.7–14.3)
|
3.1 (0.3–10.0)
|
2.3 (0.6–10.8)*
|
|
Total cells, 106
|
6.7 (1.4–54.5)
|
4.1 (1.1–15.3)
|
3.5 (0.2–23)*
|
|
Cell conc., 103/ml
|
1507 (484–9620)
|
2134 (534–4146)
|
1445 (303–4592)
|
|
Nonsquamous cells, %
|
94 (75–99.7)
|
92 (81–96)
|
88 (64–99.5)
|
|
Eosinophils, 103/ml
|
15 (0–106)
|
20 (0–135)
|
13 (0–235)
|
|
%
|
1.4 (0–4.0)
|
1.8 (0–4.1)
|
0.8 (0–12.6)
|
|
Neutrophils, 103/ml
|
870 (235–7608)
|
1575 (434–2558)
|
661 (164–2856)
|
|
%
|
72.6 (45–89)
|
66 (39–81)
|
60.1 (31.5–92.6)* †
|
|
Macrophages, 103/ml
|
407 (89–2615)
|
535 (89–2422)
|
568 (22–1488)
|
|
%
|
25.4 (8.2–52.7)
|
28.7 (16.6–58.4)
|
36 (6.5–62.4)*
|
|
Lymphocytes, 103/ml
|
14 (0–77)
|
15 (0–62)
|
11 (1–161)
|
|
%
|
0.8 (0.1–4)
|
0.8 (0.4–1.6)
|
0.7 (0.1–3.8)
|
|
Epithelial cells, 103/ml
|
10 (0–107)
|
0.4 (0–84)
|
10 (0–55)
|
|
%
|
0.5 (0–11)
|
0.5 (0–2.5)
|
0.8 (0–6.6)
|
|
Basophils, 103/ml
|
0 (0–4)
|
0 (0–12)
|
0 (0–8)
|
|
%
|
0 (0–0.1)
|
0 (0–0.3)
|
0 (0–0.3)
|
|
IL-8, ng/ml
|
16.8 (2.1–161)†
|
8.7 (0.1–25.7)
|
5.3 (0–25)*
|
|
ECP, μg/L
|
157 (32–2700)
|
119.8 (13.3–238)
|
66 (4.7–1282)*
|
- Values expressed in median (range). Abbreviations: cell conc. = cell concentration; IL-8 = interleukin-8; ECP = eosinophilic cationic protein.
- * p < 0.05 asymptomatic smokers versus total COPD (I-III), Mann-Whitney -U test, † p < 0.05 versus GOLD stage 0, Mann-Whitney-U test.
