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Table 1 Ventilatory parameters at baseline (90% O2) before hyperoxia, after hyperoxia and during recovery.

From: Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury

  IGF-1R+/+ IGF-1Rneo/-
  Before hyperoxia After hyperoxia During recovery Before hyperoxia After hyperoxia During recovery
VE 2.03 ± 0.17 2.35 ± 0.32 # 2.84 ± 0.69# 2.27 ± 0.22 * 2.93 ± 0.37 *# 3.30 ± 0.62#
VT 10.0 ± 0.5 15.8 ± 2.0# 14.4 ± 2.2# 11.2 ± 0.8 * 15.2 ± 1.1# 14.8 ± 1.1#
fR 203 ± 9 142 ± 30# 196 ± 32 203 ± 21 192 ± 18 *# 222 ± 35
  1. Values are mean parameters ± SD in IGF-1R+/+ mice (n = 6) and IGF-1Rneo/- mice (n = 5) mice; VE, minute ventilation expressed in ml/min/g, VT, tidal volume in μl/g, fR, respiratory frequency in c/min; # significant difference relative to control before hyperoxia; * significant difference between the two genotypes (P < 0.05).