Figure 8
From: Airway epithelial cell tolerance to Pseudomonas aeruginosa
IRAK1 functions in the TLR and IL-1β pathway upstream of convergence with the TNFα pathway. A simplified diagram illustrating portions of the TLR, IL-1β and TNFα signalling pathways. Consistent with our observations, disruption of IRAK1 inhibits TLR and IL-1β, but not TNF, activation of NF-κB.