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Table 3 Effects of vaccination with CpG-ODN (prevention study) on eosinophil and total BAL cell recruitment.

From: Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice

Treatment

Genotype

Total cells

Eosinophils

Monocytes

Lymphocytes

Neutrophils

PBS

B10.RIII

245 ± 43

3 ± 1

232 ± 20

5 ± 1

5 ± 1

 

IFN-β-/-

259 ± 14

3 ± 1

242 ± 33

6 ± 1

8 ± 2

OVA

B10.RIII

622 ± 37*

381 ± 43*

144 ± 17

62 ± 3*

35 ± 2*

 

IFN-β-/-

683 ± 66*

427 ± 83*

178 ± 22

55 ± 8*

22 ± 4*

OVA+CpG

B10.RIII

227 ± 18†

2.7 ± 2†

142 ± 19

67 ± 4

14 ± 1

 

IFN-β-/-

574 ± 32

52 ± 7 † ‡

321 ± 39† ‡

130 ± 38† ‡

70 ± 22† ‡

  1. Cell types quantified in BALF were eosinophils, macrophages, lymphocytes and neutrophils and are expressed as no. of cells × 103/ml. n = 5/group, *P < 0.05 vs. untreated groups. † P < 0.05 vs OVA-treated mice. ‡ P < 0.05 vs WT mice treated with CpG-ODN. OVA-treated mice and control groups.