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Table 2 Histopathologic evaluation of joints for arthritis changes.

From: Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice

Groups

Vaccination

 

CpG-ODN

Control

IFN-β-/- (n.1)

++

-

IFN-β-/- (n.2)

++

-

IFN-β-/- (n.3)

+

-

WT (n.1)

++

-

WT (n.2)

-

-

WT (n.3)

-

-

  1. Hematoxylin-eosin staining of joints from four different groups of mice (IFN-β-/- and their WT littermates with CPG-ODN treatment or control) were analyzed. This revealed mild synovitis and pannus formation in 3/3 IFN-β-/- mice treated with CPG-ODN and 1/3 WT treated with CPG-ODN while no pathological changes were observed in these two non-treated groups.