Groups | Vaccination |
---|
| CpG-ODN | Control |
---|
IFN-β-/- (n.1) | ++ | - |
IFN-β-/- (n.2) | ++ | - |
IFN-β-/- (n.3) | + | - |
WT (n.1) | ++ | - |
WT (n.2) | - | - |
WT (n.3) | - | - |
- Hematoxylin-eosin staining of joints from four different groups of mice (IFN-β-/- and their WT littermates with CPG-ODN treatment or control) were analyzed. This revealed mild synovitis and pannus formation in 3/3 IFN-β-/- mice treated with CPG-ODN and 1/3 WT treated with CPG-ODN while no pathological changes were observed in these two non-treated groups.