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Table 1 Eosinophils in airways with different dose of intranasal CpG-ODN

From: Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice

Treatment

Genotype

Eosinophils

PBS

B10.RIII

0.5 %

 

IFN-β-/-

0.7 %

OVA

B10.RIII

55 %

 

IFN-β-/-

62 %

OVA+CPG 5 μ

B10.RIII

2.1 %

 

IFN-β-/-

9.2 %

OVA+CPG 10 μ

B10.RIII

1. 9 %

 

IFN-β-/-

9.4 %

OVA+CPG 20 μ

B10.RIII

1.9 %

 

IFN-β-/-

9.0 %

  1. B10.RIII/WT (□) and IFN-β-/- (■) mice were sensitized to OVA by intraperitoneal injection and subsequently challenged with OVA either alone or with different dose of CpG-ODN by intranasal drops on days 14 and 16. Eosinophil percentage in bronchoalveolar lavage with different dose of intranasal CpG-ODN were similar in all IFN-β-/- treated mice.