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Figure 2 | Respiratory Research

Figure 2

From: Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice

Figure 2

BALF cytokine (protein) concentrations after intranasal CpG-ODN. BALF were collected 24 h after the last challenge from each group (n = 5/group) and cytokine levels determined by ELISA in non-immunized, OVA-challenged, and OVA-challenged/CpG-treated B10.RIII (□) and IFN-β-/- (■) mice at days 14 and 16. IL-5 (A) levels were significantly augmented after OVA challenge and diminished after CpG vaccination in both strains similarly. IFN-γ (B) was not induced in OVA/primed-OVA/challenge, but was induced after CpG vaccination. IFN-γ was stronger induced in B10.RIII than in IFN-β-/- mice. Th1/T2 ratio was stronger skewed to Th1-profile in B10.RIII than in IFN-β-/- mice. Data are given as mean ± SEM, *P < 0.05 vs. OVA groups. † P < 0.05 vs B10.RIII mice treated with CpG

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Respiratory Research

ISSN: 1465-993X

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