Skip to main content
Figure 1 | Respiratory Research

Figure 1

From: Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy

Figure 1

VISTA plot [24] displaying evolutionarily conserved sequences identified by the comparison of ~48 kb of human 5q31 DNA encoding the IL4, IL13 and KIF3A genes with murine sequences (BAC clone AF276990). On the horizontal axis, conserved sequences are plotted in relation to their position in the human reference sequence; kb distances are shown under the horizontal bar. The height of the peaks on the vertical axis indicates the level of conservation in percent identity between the human reference sequence and the murine sequences. Conserved sequences (>100 bp and >70% identity) defined as coding exons (dark blue), untranslated exons (light blue) and non-coding (red) are shown. The exons in each of three genes are shown as rectangle boxes; only the 3' end (exons 9 through 16) of KIF3A is shown. Six conserved non-coding elements were examined in this study (CNE-A - CNE-F). The SNPs identified or genotyped in this study and their approximate locations are shown. CNE-B corresponds to CNS-1 and CNE-F corresponds to CNS-2 described by Loots et al. [4].

Back to article page