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Table 3 Sensitivity and specificity of response to mannitol compared to hypertonic saline and a clinical assessment of asthma (Clinical Dx)

From: The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline

  Sensitivity (95% CI) Specificity (95% CI)
Mannitol vs Hypertonic Saline 80.7 (76.4, 85.1) 86.7 (82.6, 90.7)
Mannitol vs Clinical Dx 59.8 (55.4, 64.2) 94.5 (89.9, 99.2)
Hypertonic Saline vs Clinical Dx 65.1 (60.9, 69.3) 95.2 (91.1, 99.3)
Excluding all taking ICS   
Mannitol vs Clinical Dx 70 (62.1, 78.2) 95 (90.7, 99.3)
Excluding M-ve taking ICS   
Mannitol vs Clinical Dx 89 (85.3, 92.1) 95 (90.7, 99.3)