Figure 5

Concentrations of aerosolised MCh required to induce a doubling of the response to saline in the airways (A), or a 50% increase in the response of the lung parenchyma (B, C) of adult mice. Significantly lower concentrations of MCh were required to induce responses at 5 and 7 d post infection in Raw and H (A, C), and at 7 d in G (B). A mixed response was evident at 10 d post infection in both airway and tissue compartments.