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Table 1 Cell proliferation in mechanically wounded NCI-H292 cell monolayers: effect of CSC.

From: Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione

 

% BrdU positive nucleia

Stimuli

BrdU incubation period

 

24–48 h

48–72 h

 

wound

intact

wound

intact

Medium

21.5 ± 0.7

17.0 ± 1.6

20.9 ± 1.0

12.4 ± 1.4

TGFα

47.3 ± 3.9*

34.9 ± 1.5*

27.5 ± 0.5*

16.4 ± 2.2

NAC

22.5 ± 2.9

16.3 ± 1.8

20.5 ± 1.1

14.4 ± 1.3

CSC 1 AU/ml

39.8 ± 1.0*

29.5 ± 3.8*

42.2 ± 1.6*

24.0 ± 2.3

CSC 1 AU/ml+NAC

25.7 ± 0.7ˆ

17.4 ± 2.7ˆ

21.8 ± 2.5ˆ

16.0 ± 1.8ˆ

  1. aPercentage BrdU-positive nuclei within a distance of 10 cells from the wound edge (i.e. within the original wound area) and in intact areas. Data are mean ± SEM of 3 independent experiments. *: p < 0.05 versus serum-free medium-treated cells. ˆ:p < 0.05 vs CSC 1 AU/ml
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Respiratory Research

ISSN: 1465-993X

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