TY - JOUR AU - Luppi, Fabrizio AU - Aarbiou, Jamil AU - van Wetering, Sandra AU - Rahman, Irfan AU - de Boer, Willem I. AU - Rabe, Klaus F. AU - Hiemstra, Pieter S. PY - 2005 DA - 2005/11/25 TI - Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione JO - Respiratory Research SP - 140 VL - 6 IS - 1 AB - Increased airway epithelial proliferation is frequently observed in smokers. To elucidate the molecular mechanisms leading to these epithelial changes, we studied the effect of cigarette smoke condensate (CSC) on cell proliferation, wound closure and mitogen activated protein kinase (MAPK) activation. We also studied whether modulation of intracellular glutathione/thiol levels could attenuate CSC-induced cell proliferation. SN - 1465-993X UR - https://doi.org/10.1186/1465-9921-6-140 DO - 10.1186/1465-9921-6-140 ID - Luppi2005 ER -