Figure 5
From: Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema
AAT-deficiency emphysema (case 1): Electron micrograph showing (a) early apoptosis with perinuclear chromatin condensation (arrow) and (b) late apoptosis with nuclear dense chromatin of pneumocytes (arrow). (c) An endothelial cell with condensed chromatin is well visible (arrow). (d) Note reduplication of the vessel basal membrane (arrow). In (e) and (f) apoptotic bodies in various degrees of degradation close to a macrophage and an intraluminal apoptotic body are well visible (arrows).