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Table 1 Patient characteristics and overview on lavages performed

From: Therapeutic lung lavages in children and adults

Patients

Sex

Body weight

age at diagnosis

age at follow up

number of lavage sessions

number of 500 ml portions per lavage

total lavage volume recovered per lung

volume/b.w

  

(kg)

(y)

(y)

left

right

left lung

right lung

(ml)

(ml/kg)

PAP ped. (J01)

m

8.5

1.75

5.8

9

11

9 (6.5/10)

6 (4/7)

3258 (2780/4080)

383.3

PAP ped. (J02)

f

14.5

1.75

7.8

6

6

7.5 (5.5/10)

7 (5.5/9.5)

3353 (2862/3913)

231.2

PAP ped. (J03)

f

4.5

0.33

died at age 1/3

1

1

2

8

270.3

60.1

PAP ped. (J04)

m

4.3

0.08

died at age 1/4

1

1

2

4

1018.3

236.8

median (25/75 percentile)

 

6.5 (4.4/11.5)++

1.0 (0.2/2.3)++

     

2007 (644.3/3199)

234 (145.7/310)

PAP adult (A01)

f

70.0

39.5

alive

1

1

28

29

14102

201.5

PAP adult (A02)

f

69.6

39

alive

1

0

13

0

6608

94.4

PAP adult (A03)

f

69.7

49

alive

0

1

0

35

17659

252.3

PAP adult (A04)

f

70.2

37

alive

0

1

0

27

27000

385.7

PAP adult (A05)#

m

80.5

51.5

alive

1

1

20

24

22000

275

PAP adult (A06)#

m

80.1

43.5

alive

1

1

31

39

35000

437.5

median (25/75 percentile)

70.1 (69.7/80.3)

42 (38/50)

     

19830 (10355/31000)$$

263.7 (248/411.6)$

Cholesterol – Pneumonitis (L01)

m

13

6.5

13.5. LTX

1

1

n.a.

2

577.5

44.4

control (C01)

f

13

1.5

n.a.

0

1

n.a.

n.a.

12

0.9

control (C02)

m

20

5

n.a.

0

1

n.a.

n.a.

48

2.4

control (C03)

m

16

4

n.a.

0

1

n.a.

n.a.

23

1.4

control (C04)

m

11

3

n.a.

0

1

n.a.

n.a.

17

1.6

control (C05)

f

11

2.5

n.a.

0

1

n.a.

n.a.

21

1.9

control (C06)

m

8.5

1.5

n.a.

1

0

n.a.

n.a.

21

2.5

control (C07)

f

7

0.5

n.a.

1

0

n.a.

n.a.

12.5

1.8

control (C08)

m

10

1.5

n.a.

1

0

n.a.

n.a.

14

1.4

control (C09)

m

11

2

n.a.

1

0

n.a.

n.a.

17

1.6

control (C10)

m

36

10.5

n.a.

1

0

n.a.

n.a.

65

1.8

median (25/75 percentile)

 

11 (9.3/18)

2.3 (1.5/4.5)

     

19 (13.3/35)

1.7 (1.4/2.2)

  1. n.a. = not applicable. b.w. = body weight. Only diagnostic bronchoalveolar lavage. i.e. 4 ml/kg in 4 fractions; LTX = lung transplantation; data are presented as median (25/75 percentile); y = years; # = every portion consists of 1000 ml, total protein of 500 ml portions calculated; BAL = bronchoalveolar lavage; f = female; m = male; All three groups (PAP ped, PAP adult and controls) were compared by Friedmann (ANOVA), followed by Dunn's post-hoc-test: +: p < 0.05, ++: p < 0.01, +++: p < 0.001 indicate differences between pediatric PAP and adult PAP. §: p < 0.05, §§: p < 0.01, §§§: p < 0.001 indicate differences between pediatric PAP and controls. $:p < 0.05, $$: p < 0.01, $$$: p < 0.001 indicate differences between adult PAP and controls.