Figure 2

Immunohistochemical localization of cell-associated INFγ and IL-4 in NSIP and UIP lung biopsies. NSIP tissue exhibited diffuse expression of INFγ on lymphocytes. INFγ was also associated with macrophages and epithelial cells. Few cells stained positive for IL-4 in NSIP lung. Both stains were also significantly less prominent in UIP. The percentage of stained cells was enumerated for the NISP and UIP samples. Values are reported as mean ± SEM for 10 NSIP and 8 UIP biopsies. (* Denotes significant differences in the extent of cellular staining, for INFγ P = 0.0005, for IL-4 p = 0.045 comparing NSIP and UIP by Wilcoxon/Kruskal-Wallis Tests).