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Figure 1 | Respiratory Research

Figure 1

From: Membrane TNF confers protection to acute mycobacterial infection

Figure 1

Defective soluble TNF and augmented IL-12 production from mycobacterial stimulated macrophages, and normal upregulation of CD40 and CD86 costimulatory molecules. Mycobacteria induced TNF (A) and IL-12p40 (B) production at 24 h TNF in the supernatant of macrophages from WT (open bars), TNF-deficient (black bars) and mem-TNF mice (grey bars) infected with BCG or H37Rv (at a MOI of 2) or stimulated with LPS (100 ng/ml). Data are expressed as the mean ± SD (n = 2 mice from one out of 4 independent experiments). TNF independent expression of costimulatory molecules CD40 (C) and CD86 (D) analysed by flow cytometry in macrophages stimulated as above. Results are expressed as mean percentage.

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