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Table 1 mRNA profile of cytokine and chemokine gene expression of primary culture of human type II pneumocytes 3 h and 6 h after infection with A/Hong Kong/483/97 (H5N1/97), A/Vietnam/1194/04, A/Vietnam/3046/04 (both H5N1/04) and A/Hong Kong 54/98 (H1N1) influenza viruses denoted as fold increase compared to mock infected cells.

From: Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

Gene products

Ratio of expression over mock-infected cells

 

3 hours post infection

6 hours post infection

 

483/97 (H5N1/97) (-â– -)c

1194/04 (H5N1/04) (-â—†-)c

3046/04 (H5N1/04) (-×-)c

54/98 (H1N1) (-â–²-)c

483/97 (H5N1/97) (-â– -)c

1194/04 (H5N1/04) (-â—†-)c

3046/04 (H5N1/04) (-×-)c

54/98 (H1N1) (-â–²-)c

Interleukin 1

-1.2

0.3

0.9

1.1

1

0.9

0.8

-1.3

Interleukin 6

9.3*a

15.1*b

9.9*a

7.4*a

17.4*b

19.2*b

15.4*b

8.8*a

Interleukin 8

1

0.9

1.1

-1.2

-1.2

1.6

1.3

1.3

MCP-1

1.1

0.8

1.5

1

-1.2

1.7

1.3

1.3

TNF alpha

Not detectable

Not detectable

RANTES

-1

9.5*a

2.2*

1.55

18.7*b

24.1*b

16.9*b

6.9*a

Interferon-alpha

1.1

0.8

0.6

1.2

-1.3

1.3

0.9

1.2

Interferon-beta

3.7*a

8.5*a

4.7*a

-0.8

22.1*b

26.3*b

18.7*b

13.3*b

IP-10

3.9*a

7.9*a

6.3*a

-3.5

37.9*b

46.8*b

29.7*b

8.1*a

  1. Signals were normalized to the housekeeping gene, β-actin and expressed as a ratio over mock infected cells.
  2. *Upregulation by two or more times over that of mock infection.
  3. ap < 0.01 and bp < 0.001 (Bonferroni multiple-comparison test).
  4. c Corresponding character symbols as shown in Figure 3 and 4.