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Table 1 Lung leukocyte populations in SP-D-/- and SP-D+/+ mice at time zero, 24 and 48 hrs post-intranasal pneumococcal challenge. Leukocyte subpopulations (neutrophils, T cells, macrophages and B cells) numerated in the vicinity of inflamed bronchioles were expressed as cells per mm2 lung tissue. Leukocyte subpopulations expressed as the percentage of total lung leukocytes are shown in parenthesis. Fold increases in leukocytes subpopulations compared to time zero levels. N = 4 mice per each time point analysed for all samples. "a" denotes P < 0.01, "b" denotes P < 0.05 as compared to time zero values. "c" denotes P < 0.01, "d" denotes P < 0.05, SP-D-/- mice compared to SP-D+/+ mice at equivalent time-point.

From: The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia

A) Neutrophils SP-D+/+ mice SP-D-/- mice
Time Cells/mm2 Fold increase Cells/mm2 Fold increase
Zero: 11 +/- 2   9 +/-2  
24: 60 +/-5 a (70%) 5.4 70+/-8a (53%) 7.7
48: 72 +/-7 a (73%) 6.5 47 +/-4 b, d (59%) 5.2
B) T cells SP-D+/+ mice SP-D-/- mice
Time Cells/mm2 Fold increase Cells/mm2 Fold increase
Zero: 9 +/-1   8 +/-2  
24: 9 +/-1 (11%) no change 48 +/-8 a, c (36%) 6
48: 8 +/-1 (8%) no change 16 +/-4 b, d (20%) 2
C) Macrophage SP-D+/+ mice SP-D-/- mice
Time Cells/mm2 Fold increase Cells/mm2 Fold increase
Zero: 7 +/-1 no change 7 +/-1  
24: 8 +/-2 (9%) no change 8 +/-3 (6%) no change
48: 9 +/-2 (9%) no change 8 +/-2 (10%) no change
D) B cells SP-D+/+ mice SP-D-/- mice
Time Cells/mm2 Fold increase Cells/mm2 Fold increase
Zero: 8 +/-1   6 +/-1  
24: 8 +/-2 (9%) no change 7 +/-3 (5%) no change
48: 9 +/-2 (9%) no change 9 +/-1 (11%) no change