Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys

Table 3 Incidence of MnSO₄-induced microscopic lesions observed in young male rhesus monkeys exposed to MnSO₄. Incidence is expressed as number affected/number examined.

Lesion	MnSO₄ exposure concentration (mg Mn/m³)	15	33	Exposure Day 65	65 [+45]^a	65 [+90]^a
Subacute bronchiolitis/alveolar duct inflammation	0			0/6
	0.06			0/6
	0.3			1/4^b
	1.5	3/4*	4/4*	3/4*	0/4	1/4
Increased bronchus associated lymphoid tissue	0			0/6
	0.06			0/6
	0.3			1/4
	1.5	2/4^†	3/4*	1/4	2/4^†	1/4

^a Number in brackets indicates number of days post exposure assessment
^b Subacute bronchiolitis was observed in one monkey; however, in this animal only, this lesion was observed in conjunction with aspirated food particles.
* p < 0.05 (Pearson's chi-square test)
^† p = 0.053 (Pearson's chi-square test)

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