Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study

Respiratory Research

Table 3 Incidences and hazard ratios for COPD hospitalisation by intron-8 polythymidine tract and F508del genotype during 24 years follow-up

Poly-T	Expected exon-9 skipping, %	F508del heterozygosity	n	Incidence n/10000 person-years	P-value*	Unadjusted HR (95%CI)	Adjusted^† HR (95%CI)	90% power^‡ HR
9T/9T	7		83	40	0.10	1.8 (0.89–3.6)	1.7 (0.85–3.5)	2.3
7T/9T	13		1540	21	0.70	0.95 (0.75–1.2)	0.99 (0.78–1.3)	1.3
7T/7T	18		6905	22	-	1.0	1.0	-
6T/7T	≥18		4	105	0.08	4.9 (0.69–35)	7.6 (1.0–55)	11
5T/9T	43		40	21	0.90	0.92 (0.23–3.7)	0.75 (0.19–3.0)	3.0
5T/7T	48		308	11	0.03	0.47 (0.23–0.95)	0.49 (0.23–1.0)	1.6
5T/5T	78		2	0	0.73	-	-	19
9T/9T	-	yes	23	0	0.25	-	-	3.8
7T/9T	-	yes	217	25	0.73	1.1 (0.63–1.9)	1.1 (0.62–1.9)	1.7
7T/7T	-	yes	5	0	0.59		-	9.7
5T/9T	-	yes	4	0	0.63	-	-	11

*P-values are for the comparison with 7T/7T individuals without the F508del deletion by log-rank test. ^†Cox regression adjusted for gender, age at study entry, tobacco use during follow-up, and FEV₁ % predicted at study entry. ^‡90% power to detect a hazard ratio (HR) of COPD at 2-sided P < 0.05. 95%CI = 95% confidence interval. Hospitalizations from COPD (ICD8: 491–492; ICD10: J41–44) were drawn from the Danish National Discharge Register from 1976 through 2000.

ISSN: 1465-993X