Figure 5
From: The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis
A: Time-dependent IL-10 production in the lung of NMRI mice in the fibrosing alveolitis (FA), resolving alveolitis (RA) and non-inflammatory models (NI). Bars represent means +/- SEM of 5 to 6 animals. Significant differences from controls: *P < 0.05 (Student-Newman-Keuls multiple comparison test). B: Cellular immuno-localization of IL-10 production in the FA model at day 120. Mainly macrophages having phagocytozed silica particles expressed IL-10. C: IL-10 contents in lung homogenates of BALBc, C57BL/6 and DBA/2 mice 60 days after intratracheal instillation of silica (2.5 mg). DBA2 mice developed the most severe fibrotic lesions and expressed the highest IL-10 levels. The results for individual mice are shown. The bars denote the mean values for each group (n = 8 to 9). Significantly different from controls: *P < 0.05 (Student-Newman-Keuls multiple comparison test).