IL-8 production by various clones in response to exposure to LPS and TNF-α. Equal cell numbers from clones were exposed to a concentration range of LPS (see z-axis; 0–1 μg/ml, A) or TNF-α (0–5 ng/ml, B) for 8 hrs. IL-8 in culture supernatant was measured by ELISA. T represents the mean IL-8 production (in pg/ml; y-axis) of 7 T-clones. Individual B and AB clones as designated on the x-axis. Data are shown as the mean of two independent experiments (triplicate samples). Due to the representation as a 3D-matrix, no standard deviation can be shown. Asterisks indicates significant (* = p < 0.05, ** = p < 0.01, *** = p < 0.001) hyperresponsiveness, # indicates significant hyporesponsiveness (# = p < 0.05, ## = p < 0.01, ### = p < 0.001).