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Table 3 Levels of pro-MMP-9 and TIMP-1, and pro-MMP-9 / TIMP-1 ratio in BAL supernatant fluids, recovered from p47phox +/+ [WT] and p47phox -/- [KO] mice, 1 day or 14 days after intranasal administration of bleomycin (BLM, 0.1 mg/mouse) or saline vehicle (Control, NaCl 0.9%). For Pro-MMP-9 and TIMP-1, results are represented as the mean (pg/ml) ± SEM. N : number of mice. a : P < 0.05, b : P < 0.01, in comparison to control mice exposed to saline solution only. * : P < 0.05, ** : P < 0.01, for [KO] mice in comparison to [WT] mice.

From: The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis

Treatment

Strain

N

Pro-MMP-9

TIMP-1

Ratio Pro-MMP-9 / TIMP-1

Control

[WT]

5

46.3 ± 14.9

38.7 ± 13.5

2.7 ± 1.3

 

[KO]

5

1314.7 ± 798.2 **

325.2 ± 173.6

10.4 ± 4.7

BLM, day 1

[WT]

7

2645.9 ± 1 011.6 b

781.8 ± 158.9 b

3.8 ± 1.3

 

[KO]

8

23646.8 ± 2 359.7 b, **

1 213.8 ± 396.4

60.8 ± 23.7 a, **

BLM, day 14

[WT]

7

37.7 ± 9.1

2693.3 ± 378.3 b

0.02 ± 0.00 b

 

[KO]

6

137.9 ± 15.5 b

567.9 ± 163.5**

0.2 ± 0.1 b, **