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Table 4 Differences in area under the salbutamol response curve (AUC)

From: Tolerance to bronchodilation during treatment with long-acting beta-agonists, a randomised controlled trial

  

Day 1

Day 8

AUC as % of fall in FEV1 (%.time) mean and SD

Placebo

196 (74)

205 (63)

 

Formoterol

120 (61)

107 (53)

 

Difference (least squares means, 95% confidence interval)

13.06 (-50.4, 76.53)

85.44 (31.78, 139.1)

  

P = 0.944

P = 0.001

Final FEV 1 (L) mean and SD

Placebo

3.32 (0.84)

3.31 (0.89)

 

Formoterol

3.25 (0.22)

3.12 (0.84)

 

Difference (least squares means, 95% confidence interval)

0.06 (-0.18, 0.30)

0.26 (0.06, 0.46)

  

P = 0.909

P = 0.006

  1. Differences in AUC by treatment and time using Tukey's exact method from covariate analysis (n = 13)