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Table 2 Changes in FEV1, PD20 and fall in FEV1

From: Tolerance to bronchodilation during treatment with long-acting beta-agonists, a randomised controlled trial

  

Day 1

Day 8

Pre-methacholine FEV 1 (L) Mean and SD

Placebo

3.26 (0.84)

3.24 (0.86)

 

Formoterol

3.44 (0.80)

3.36 (0.89)

 

Difference (95% CI)

0.18 (0.08, 0.28)

0.12 (-0.01. 0.24)

  

P = 0.002

P = 0.069

PD 20 (mg) Geometric mean and 95% CI for mean

Placebo

0.10 (0.04, 0.24)

0.12 (0.04, 0.32)

 

Formoterol

0.45 (0.15, 1.35)

0.17 (0.05, 0.60)

 

Difference (doubling doses) (95% CI)

2.12 (0.88, 3.36)

0.51 (-0.49, 1.51)

  

P = 0.003

P = 0.286

Fall in FEV 1 from baseline (%) Mean and SD

Placebo

24.78 (4.74)

23.73 (4.54)

 

Formoterol

24.56 (5.24)

22.26 (4.34)

 

Difference (95% CI)

-0.22 (-3.54, 3.10)

-1.47 (-4.61, 1.66)

  

P = 0.886

P = 0.327

  1. N = 13. As there is no data on subject 6 for day 8 placebo, data from day 1 have been used to calculate means.