Day 1 | Day 8 | ||
---|---|---|---|
Pre-methacholine FEV 1 (L) Mean and SD | Placebo | 3.26 (0.84) | 3.24 (0.86) |
Formoterol | 3.44 (0.80) | 3.36 (0.89) | |
Difference (95% CI) | 0.18 (0.08, 0.28) | 0.12 (-0.01. 0.24) | |
P = 0.002 | P = 0.069 | ||
PD 20 (mg) Geometric mean and 95% CI for mean | Placebo | 0.10 (0.04, 0.24) | 0.12 (0.04, 0.32) |
Formoterol | 0.45 (0.15, 1.35) | 0.17 (0.05, 0.60) | |
Difference (doubling doses) (95% CI) | 2.12 (0.88, 3.36) | 0.51 (-0.49, 1.51) | |
P = 0.003 | P = 0.286 | ||
Fall in FEV 1 from baseline (%) Mean and SD | Placebo | 24.78 (4.74) | 23.73 (4.54) |
Formoterol | 24.56 (5.24) | 22.26 (4.34) | |
Difference (95% CI) | -0.22 (-3.54, 3.10) | -1.47 (-4.61, 1.66) | |
P = 0.886 | P = 0.327 |