LIGANDS | DOWN REGULATION | IMPLICATION | UP REGULATION | IMPLICATION |
---|---|---|---|---|
TZDs (Exogenous) | Cytokines (IL-8, IL-4, IL-5, IL-6 and IL-13) NOS MCP-1 | Asthma and other pulmonary inflammatory diseases | aP2 UCP1 UCP3 Acrp30 | Insulin resistance Obesity Hyperlipidaemia |
NSAIDs (Exogenous) | SP-B AHR | |||
15D-PGJ2 (Endogenous) | TGF-β GATA-3 IgE and lgG1 | |||
IL-4 (Endogenous) | T-cell response MMP-9 G-CSF and KC | |||
azelaoyl-phosphocholine (Endogenous) | GM-CSF | COPD | FATP-1 LPL (Adipose tissue) | Atherosclerosis |
Eicosenoids (Endogenous) | Cyclin D1 NF-κB PGE2 EP2 | Lung cancer (NSCLC, LCC) |