Figure 2
Activation of PPAR-γ by endogenous (15D-PGJ2) and exogenous (TZDs) ligands results in transcription of wide array of genes that can control pathogenesis of acute and chronic disorders in various tissues of lungs. Please refer text for more information. Abbreviations: 15D-PGJ2: 15-deoxy-Δ12,14-prostaglandin J2, Cpla2: cytosolic phospholipase A2, TZDs: Thiozolidinediones NSAIDs: Non-steroidal anti-inflammatory drugs MCP:1monocyte chemoattractant protein, G-CSF: granulocyte-colony-stimulating factor, GM-CSF:granulocyte-macrophage-colony-stimulating factor, KC: keratinocyte-derived chemokine, NOS: Nitric oxide synthases, SP-B: surfactant proteins-B, MMP-9: matrix metalloproteinase 9, TGF-β: Transforming growth factor-β, IgE and IgG1: Immunoglubulin E and Immuno globulin G1, NF-κB: Nuclear factor-κB, EP2: Prostaglandin E2 receptor, PGE2: Prostaglandin E2, aP2: Adipocyte fatty acid binding protein, UCP 1&3: Uncoupling proteins 1 & 3, Acrp30: Adipocyte complement related factor 30, FATP-1: Fatty acid transport protein-1.