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Table 1 Effect of hyperoxia on GSH reductase activity, and on GSH and GSSG content in TIIcells

From: Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells

 

Control

Hyperoxia

GSH reductase (% of control)

100

76 ± 10*

GSH (μmol/mg protein)

0.022 ± 0.015

0.020 ± 0.008

GSSG (μmol/mg protein)

0.005 ± 0.0015

0.013 ± 0.001*

GSH/(GSH+GSSG) (ratio)

0.81

0.61

  1. Activity of glutathione (GSH) reductase and concentration of GSH and GSSG were determined in freshly prepared TIIcells of rats exposed to air (control) or oxygen for 48 hrs (hyperoxia) as described in Materials and Methods. Values are means ± standard deviation of n = 3 independent experiments. Asterisk indicates a significant difference to control (p < 0.05).
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Respiratory Research

ISSN: 1465-993X

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