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Table 2 Inhibitory potency (μM) of study compounds against cloned human PDE's. Measurements were determined by a modification of the 2 step procedure described by Thompson and Applegate (1971).

From: The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

 

PDE 3 (IC50)

PDE 4 (IC50)

PDE 5 (IC50)

Cilostazol

3.7

>100

Nil

Ro 20-1724

Nil

1.3

Nil

Sildenafil

Nil

Nil

0.061

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Respiratory Research

ISSN: 1465-993X

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