Table 3 Expression of nAChR in HBE and Bronchial Epithelial Cells Lines as determined by RT-PCR
HBE | α1 | α3 | α5 | α6 | α7 | α9 | β1 | β2 | β3 | β4 * | δ | ε |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Never smoker | 2/9 (22%) | 2/8 (25%) | 6/9 (67%) | 5/9 (56%) | 7/9 (78%) | 8/8 (100%) | 9/9 (100%) | 4/7 (57%) | 0/8 (0%) | 6/9 (67%) | 7/8 (88%) | 5/9 (56%) |
Active smoker | 3/10 (30%) | 0/3 (0%) | 9/10 (90%) | 3/4 (75%) | 7/10 (70%) | 3/3 (100%) | 9/10 (90%) | 5/9 (56%) | 0/5 (0%) | 1/10 (0%) | 6/8 (75%) | 7/10 (70%) |
Ex-smoker | 7/18 (39%) | 8/19 (42%) | 18/19 (95%) | 9/19 (47%) | 11/18 (61%) | 16/18 (89%) | 17/19 (89%) | 6/16 (38%) | 1/19 (5%) | 9/19 (47%) | 11/18 (61%) | 10/19 (53%) |
Total | 12/37 (32%) | 10/30 (33%) | 33/38 (87%) | 17/32 (53%) | 25/37 (68%) | 27/29 (93%) | 35/38 (92%) | 15/32 (47%) | 1/32 (3%) | 16/38 (42%) | 24/34 (70%) | 22/38 (58%) |
BEAS2B | + | - | + | + | + | + | + | + | - | + | + | + |
IB3-1 | + | - | + | - | + | + | + | + | - | + | + | + |