Table 2 TGFβ-regulated signalling and ECM/cytoskeletal genes in control and fibrotic lung fibroblasts
From: Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts
Gene Symbol | Affymetrix Probe N | Control LF* | Fibrotic LF* | Gene name |
|---|---|---|---|---|
Signal transduction | ||||
ACVR1 | 39764_at | 2.2 | 1.7 | activin A receptor, type I |
ADM | 34777_at | 0.3 | 0.4 | adrenomedullin |
AGTR1 | 346_s_at | 3.8 | 3.2 | angiotensin II receptor, type 1 |
AGTR1 | 37983_at | 5.1 | 5.9 | angiotensin II receptor, type 1 |
BDKRB2 | 39310_at | 0.4 | 0.4 | bradykinin receptor B2 |
BMP4 | 1114_at | 0.2 | 0.2 | bone morphogenetic protein 4 |
BMP4 | 40333_at | 0.1 | 0.3 | bone morphogenetic protein 4 |
DYRK2 | 40604_at | 3.0 | 3.0 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
DYRK2 | 760_at | 2.9 | 3.3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
DYRK2 | 761_g_at | 3.3 | 2.2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
MLP | 36174_at | 2.4 | 1.7 | MARCKS-like protein |
PLK2 | 41544_at | 0.4 | 0.6 | polo-like kinase 2 (Drosophila) |
RRAD | 1776_at | 3.0 | 5.2 | Ras-related associated with diabetes |
RRAD | 39528_at | 3.6 | 5.1 | Ras-related associated with diabetes |
SMAD3 | 38944_at | 0.4 | 0.4 | SMAD, mothers against DPP homolog 3 (Drosophila) |
SMAD7 | 1857_at | 2.3 | 2.2 | SMAD, mothers against DPP homolog 7 (Drosophila) |
SOCS1 | 41592_at | 0.1 | 0.1 | suppressor of cytokine signaling 1 |
SPRY2 | 33700_at | 2.0 | 1.8 | sprouty homolog 2 (Drosophila) |
STK38L | 32182_at | 3.7 | 3.8 | serine/threonine kinase 38 like |
TGFBR3 | 1897_at | 0.3 | 0.5 | transforming growth factor, beta receptor III (betaglycan) |
TNFRSF1B | 1583_at | 0.4 | 0.6 | tumor necrosis factor receptor superfamily, member 1B |
TNFRSF1B | 33813_at | 0.4 | 0.4 | tumor necrosis factor receptor superfamily, member 1B |
TSPAN-2 | 35497_at | 4.2 | 5.0 | tetraspan 2 |
Extracellular matrix remodelling/Cytoskeletal | ||||
COL4A1 | 39333_at | 2.2 | 2.0 | collagen, type IV, alpha 1 |
COMP | 40161_at | 2.7 | 5.3 | cartilage oligomeric matrix protein |
COMP | 40162_s_at | 5.0 | 18.9 | cartilage oligomeric matrix protein |
CTGF | 36638_at | 4.8 | 6.1 | connective tissue growth factor |
CYR61 | 38772_at | 4.4 | 3.5 | cysteine-rich, angiogenic inducer, 61 |
ELN | 31621_s_at | 4.9 | 3.7 | elastin |
ELN | 39098_at | 8.4 | 11.6 | elastin |
PLAUR | 189_s_at | 2.7 | 2.8 | plasminogen activator, urokinase receptor |
PLOD2 | 34795_at | 2.5 | 1.8 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
SERPINE1 | 38125_at | 3.7 | 4.0 | serine (or cysteine) proteinase inhibitor, clade E, member 1 |
SERPINE1 | 672_at | 6.0 | 5.5 | serine (or cysteine) proteinase inhibitor, clade E, member 1 |
TIMP3 | 1034_at | 2.0 | 1.5 | tissue inhibitor of metalloproteinase 3 |
TIMP3 | 1035_g_at | 2.4 | 1.6 | tissue inhibitor of metalloproteinase 3 |
TPM1 | 36790_at | 2.3 | 1.7 | tropomyosin 1 (alpha) |
TPM1 | 36791_g_at | 2.7 | 2.1 | tropomyosin 1 (alpha) |
TPM1 | 36792_at | 2.5 | 2.0 | tropomyosin 1 (alpha) |