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Table 2 TGFβ-regulated signalling and ECM/cytoskeletal genes in control and fibrotic lung fibroblasts

From: Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

Gene Symbol Affymetrix Probe N Control LF* Fibrotic LF* Gene name
Signal transduction
ACVR1 39764_at 2.2 1.7 activin A receptor, type I
ADM 34777_at 0.3 0.4 adrenomedullin
AGTR1 346_s_at 3.8 3.2 angiotensin II receptor, type 1
AGTR1 37983_at 5.1 5.9 angiotensin II receptor, type 1
BDKRB2 39310_at 0.4 0.4 bradykinin receptor B2
BMP4 1114_at 0.2 0.2 bone morphogenetic protein 4
BMP4 40333_at 0.1 0.3 bone morphogenetic protein 4
DYRK2 40604_at 3.0 3.0 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
DYRK2 760_at 2.9 3.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
DYRK2 761_g_at 3.3 2.2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
MLP 36174_at 2.4 1.7 MARCKS-like protein
PLK2 41544_at 0.4 0.6 polo-like kinase 2 (Drosophila)
RRAD 1776_at 3.0 5.2 Ras-related associated with diabetes
RRAD 39528_at 3.6 5.1 Ras-related associated with diabetes
SMAD3 38944_at 0.4 0.4 SMAD, mothers against DPP homolog 3 (Drosophila)
SMAD7 1857_at 2.3 2.2 SMAD, mothers against DPP homolog 7 (Drosophila)
SOCS1 41592_at 0.1 0.1 suppressor of cytokine signaling 1
SPRY2 33700_at 2.0 1.8 sprouty homolog 2 (Drosophila)
STK38L 32182_at 3.7 3.8 serine/threonine kinase 38 like
TGFBR3 1897_at 0.3 0.5 transforming growth factor, beta receptor III (betaglycan)
TNFRSF1B 1583_at 0.4 0.6 tumor necrosis factor receptor superfamily, member 1B
TNFRSF1B 33813_at 0.4 0.4 tumor necrosis factor receptor superfamily, member 1B
TSPAN-2 35497_at 4.2 5.0 tetraspan 2
Extracellular matrix remodelling/Cytoskeletal
COL4A1 39333_at 2.2 2.0 collagen, type IV, alpha 1
COMP 40161_at 2.7 5.3 cartilage oligomeric matrix protein
COMP 40162_s_at 5.0 18.9 cartilage oligomeric matrix protein
CTGF 36638_at 4.8 6.1 connective tissue growth factor
CYR61 38772_at 4.4 3.5 cysteine-rich, angiogenic inducer, 61
ELN 31621_s_at 4.9 3.7 elastin
ELN 39098_at 8.4 11.6 elastin
PLAUR 189_s_at 2.7 2.8 plasminogen activator, urokinase receptor
PLOD2 34795_at 2.5 1.8 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SERPINE1 38125_at 3.7 4.0 serine (or cysteine) proteinase inhibitor, clade E, member 1
SERPINE1 672_at 6.0 5.5 serine (or cysteine) proteinase inhibitor, clade E, member 1
TIMP3 1034_at 2.0 1.5 tissue inhibitor of metalloproteinase 3
TIMP3 1035_g_at 2.4 1.6 tissue inhibitor of metalloproteinase 3
TPM1 36790_at 2.3 1.7 tropomyosin 1 (alpha)
TPM1 36791_g_at 2.7 2.1 tropomyosin 1 (alpha)
TPM1 36792_at 2.5 2.0 tropomyosin 1 (alpha)
  1. Mean fold change in mRNA abundance in TGFβ treated/untreated control and fibrotic lung fibroblasts (LF), respectively. Fibrotic lung fibroblast ratios represent the average of idiopathic and scleroderma-associated pulmonary fibrosis lung fibroblasts.