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Table 1 Transcription factor genes regulated by TGFβ in control and fibrotic lung fibroblasts (LF)

From: Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

Gene Symbol

Affymetrix Probe N

Control LF*

Fibrotic LF*

Gene name

BHLHB2

40790_at

6.0

5.1

basic helix-loop-helix domain containing, class B, 2

CBFB

41175_at

2.9

2.8

core-binding factor, beta subunit

EGR2

37863_at

52.0

3.3

early growth response 2 (Krox-20 homolog, Drosophila)

ETV6

38491_at

2.0

2.6

ets variant gene 6 (TEL oncogene)

FOXO1A

40570_at

3.8

6.0

forkhead box O1A (rhabdomyosarcoma)

JUNB

2049_s_at

3.7

4.2

jun B proto-oncogene

JUNB

32786_at

4.4

3.0

jun B proto-oncogene

LRRFIP1

41320_s_at

2.1

1.5

leucine rich repeat (in FLII) interacting protein 1

MKL1

35629_at

2.7

2.6

megakaryoblastic leukemia (translocation) 1

MSC

35992_at

2.4

1.7

musculin (activated B-cell factor-1)

NCOR2

39358_at

2.2

2.2

nuclear receptor co-repressor 2

NPAS2

39549_at

2.4

3.1

neuronal PAS domain protein 2

NR2F2

39397_at

0.4

0.5

nuclear receptor subfamily 2, group F, member 2

NRIP1

40088_at

2.3

1.8

nuclear receptor interacting protein 1

RUNX1

393_s_at

2.3

2.6

runt-related transcription factor 1 (aml1 oncogene)

RUNX1

39421_at

3.1

2.3

runt-related transcription factor 1 (aml1 oncogene)

RUNX1

943_at

2.2

2.7

runt-related transcription factor 1 (aml1 oncogene)

SKI

41499_at

2.5

2.1

v-ski sarcoma viral oncogene homolog (avian)

SMURF2

33354_at

2.2

2.2

E3 ubiquitin ligase SMURF2

SRF

1409_at

2.1

1.9

serum response factor

SRF

40109_at

2.2

2.0

serum response factor

TCF21

37247_at

0.2

0.4

transcription factor 21

TCF8

33439_at

2.8

1.8

transcription factor 8 (represses interleukin 2 expression)

TIEG

224_at

2.2

2.1

TGFB inducible early growth response

TIEG

38374_at

3.2

2.7

TGFB inducible early growth response

ZFP36L2

32587_at

0.3

0.4

zinc finger protein 36, C3H type-like 2

ZFP36L2

32588_s_at

0.3

0.3

zinc finger protein 36, C3H type-like 2

ZNF365

35959_at

14.2

2.5

zinc finger protein 365

  1. *Mean fold change in mRNA abundance in TGFβ treated/untreated control and fibrotic lung fibroblasts (LF), respectively. Fibrotic lung fibroblast ratios represent the average values of idiopathic and scleroderma-associated pulmonary fibrosis lung fibroblasts.
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Respiratory Research

ISSN: 1465-993X

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