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Table 1 Transcription factor genes regulated by TGFβ in control and fibrotic lung fibroblasts (LF)

From: Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

Gene Symbol Affymetrix Probe N Control LF* Fibrotic LF* Gene name
BHLHB2 40790_at 6.0 5.1 basic helix-loop-helix domain containing, class B, 2
CBFB 41175_at 2.9 2.8 core-binding factor, beta subunit
EGR2 37863_at 52.0 3.3 early growth response 2 (Krox-20 homolog, Drosophila)
ETV6 38491_at 2.0 2.6 ets variant gene 6 (TEL oncogene)
FOXO1A 40570_at 3.8 6.0 forkhead box O1A (rhabdomyosarcoma)
JUNB 2049_s_at 3.7 4.2 jun B proto-oncogene
JUNB 32786_at 4.4 3.0 jun B proto-oncogene
LRRFIP1 41320_s_at 2.1 1.5 leucine rich repeat (in FLII) interacting protein 1
MKL1 35629_at 2.7 2.6 megakaryoblastic leukemia (translocation) 1
MSC 35992_at 2.4 1.7 musculin (activated B-cell factor-1)
NCOR2 39358_at 2.2 2.2 nuclear receptor co-repressor 2
NPAS2 39549_at 2.4 3.1 neuronal PAS domain protein 2
NR2F2 39397_at 0.4 0.5 nuclear receptor subfamily 2, group F, member 2
NRIP1 40088_at 2.3 1.8 nuclear receptor interacting protein 1
RUNX1 393_s_at 2.3 2.6 runt-related transcription factor 1 (aml1 oncogene)
RUNX1 39421_at 3.1 2.3 runt-related transcription factor 1 (aml1 oncogene)
RUNX1 943_at 2.2 2.7 runt-related transcription factor 1 (aml1 oncogene)
SKI 41499_at 2.5 2.1 v-ski sarcoma viral oncogene homolog (avian)
SMURF2 33354_at 2.2 2.2 E3 ubiquitin ligase SMURF2
SRF 1409_at 2.1 1.9 serum response factor
SRF 40109_at 2.2 2.0 serum response factor
TCF21 37247_at 0.2 0.4 transcription factor 21
TCF8 33439_at 2.8 1.8 transcription factor 8 (represses interleukin 2 expression)
TIEG 224_at 2.2 2.1 TGFB inducible early growth response
TIEG 38374_at 3.2 2.7 TGFB inducible early growth response
ZFP36L2 32587_at 0.3 0.4 zinc finger protein 36, C3H type-like 2
ZFP36L2 32588_s_at 0.3 0.3 zinc finger protein 36, C3H type-like 2
ZNF365 35959_at 14.2 2.5 zinc finger protein 365
  1. *Mean fold change in mRNA abundance in TGFβ treated/untreated control and fibrotic lung fibroblasts (LF), respectively. Fibrotic lung fibroblast ratios represent the average values of idiopathic and scleroderma-associated pulmonary fibrosis lung fibroblasts.