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Figure 6 | Respiratory Research

Figure 6

From: Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury

Figure 6

NO production in BAL fluid (A) and alveolar macrophages in culture (B). The groups represent rats treated as follows: Saline, saline (IT); LPS, LPS (IT); LPS-SP600125, LPS (IT) and a pretreatment with SP600125 (IO), Saline-SP600125, saline (IT) and a pretreatment with SP600125 (IO); LPS-PD98059, LPS (IT) and a pretreatment with PD98059 (IO), Saline-PD98059, saline (IT) and a pretreatment with PD98059 (IO). Animals were sacrificed 4 hours after LPS treatment. Alveolar macrophages (106/m1 of RPMI medium) were incubated for 24 hours. BAL fluid and culture supernatants were analyzed using nitrite assays. Values are represented as means ± SEM of results from 5 rats in each group. * Significant differences compared with saline, p < 0.05, and + significant difference compared with LPS group, p < 0.05.

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