The suppression of OVA-specific IgE in serum by ISS-ODN-stimulated and OVA-loaded Mφ is partially mediated by IL-10. Sensitized mice were treated (i.v.) with saline (sham), ISS-ODN-stimulated OVA-Mφ (ISS-ODN/OVA-Mφ), ISS-ODN-stimulated IL-10-/- Mφ (ISS-ODN/IL10-/-Mφ), or ISS-ODN-stimulated IL-10-/- OVA-Mφ (ISS-ODN/IL10-/-OVA-Mφ). Serum OVA-specific IgE levels were measured prior to and after OVA challenge. Values are expressed as the mean ± SEM (n = 6 to 8 per group). *P < .05 compared with sham-treated and OVA-challenged mice. †
P < .05 compared with mice treated with ISS-ODN/IL10-/-OVA-Mφ and that were OVA-challenged.