Safety assessment of inhaled xylitol in mice and healthy volunteers

Respiratory Research

Table 4 Adverse Events Score (centimeters, mean ± SD) using Visual Analog Scale (1–10)*

Symptom	Baseline VAS score	Change Post-saline	Change Post-10 ml xylitol	Change on day 5 follow-up
Chest tightness	0	0	0.2 ± 0.4	0
Shortness of breath	0	0	0	0
Cough	0.25 ± 0.8	0.05 ± 0.15	0	0
Headache	0	0	0.2 ± 0.6	0
Chills	0	0	0	0
Muscle soreness	0.2 ± 0.6	0	0	-0.2 ± 0.6
Phlegm	0.2 ± 0.6	0	0.25 ± 0.4	0
Nausea	0	0	0	0
Stuffy/Runny Nose	0	0	0.65 ± 0.9†	0
Sneezing	0	0	0	0
Fatigue	0.1 ± 0.3	0	-0.1 ± 0.3	0

*P-values of all changes from baseline are >0.05 except for stuffy nose after xylitol expsoure.
† P-value = 0.03.

ISSN: 1465-993X