Figure 3

Aspergillusantigen induced AHR in wild-type,Mcp-1^-/-andCcr2^-/-mice. Airway reactivity in response to intravenous acetylcholine was measured invasively. Data are expressed as log PC₂₀₀ and lower values indicate higher airway response. Aspergillus antigen exposure and the airway measurement protocol are described in methods (PBS-treated, N = 12 mice; Aspergillus antigen-treated, N = 8–10 mice/group;). The data shown are from one experiment and representative of three separate experiments. Asterisks (*) indicate values that are statistically significantly different (p < 0.001) compared to PBS controls.