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Figure 3 | Respiratory Research

Figure 3

From: Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry

Figure 3

Sprouty is a rapidly inducible negative regulator of fibroblast growth factor (FGF) pathway signaling. The figure shows a model describing the interaction of murine Sprouty2 (mSPRY2) with other key signaling proteins in the FGF signaling pathway. In the upper panel, the FGF pathway is shown signaling the activation of MAP kinase/ERK2 via the FGFR, FRS2, Shp2, Grb2, Sos, Ras and Raf pathway. In the lower panel Sprouty2 (SPRY2) is shown binding FRS2 and Grb2 and displacing Shp2 from FRS2 and Grb2, thereby preventing subsequent activation of the Sos, Ras-GAP, Raf pathway, resulting in net inhibition of MAP kinase/ERK2 activation.

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