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Figure 2 | Respiratory Research

Figure 2

From: Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization

Figure 2

C57BL/6 mice developed significant systemic IgE and IgG1 responses following allergenic sensitization and challenge withAfcomparable to the responses of Balb/c mice. Total serum IgE and Af-specific IgE and IgG1 profiles were analyzed by ELISA as described. Total serum IgE (panel A): expressed as ng/ml. Af-specific IgG1 and IgE (panel B and C) expressed as optical density (O.D.). Naïve mice (open bar: Balb/c (n = 15); light gray bar: C57BL/6 (n = 17)) received i.n. glycerol treatment alone. Sensitized mice (black bars: Balb/c (n = 22); dark gray bar: C57BL/6 (n = 22)) received i.p. sensitization and i.n. treatment with Af extract as described. Data are expressed as Mean ± SEM, *p < 0.05 Sensitized vs Naive; #p < 0.05 C57BL/6 vs Balb/c.

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