Figure 1

Time dependent augmentation of fibroblast-mediated collagen gel contraction induced by platelets (Plt). Fibroblasts (HFL1: 3 × 10⁵/mL gel) and Plt (10⁸/mL gel) or the two cell types together (HFL1/Plt) were cast into a 24-well tissue culture plate. The assay was performed by releasing the gels into medium immediately after gelation. The area of each gel was measured by an image analyser on four consecutive days. Vertical axis: gel area expressed as percentage of original gel size. Horizontal axis: time (days). Data are presented as mean of triplicate. Standard errors of mean (± SEM) were less than 1%. P < 0.001: HFL1 vs. HFL1/Plt on day 2.