Table 3 Comparison of Inflammatory biomarkers secreted by monocytes isolated from individuals with and without severe PiZZ AAT-deficiency
From: Circulating monocytes from healthy individuals and COPD patients
Measured Biomarker | PiMM | PiZZ | Significance | ||
|---|---|---|---|---|---|
Mean | SD | Mean | SD | P | |
MMP-9 (ng/ml) | 5 | 1.9 | 4.4 | 1 | 0.3 |
MCP-1 (pg/ml) | 498 | 124 | 348 | 95 | 0.06 |
ICAM-1(ng/ml) | 130 | 13 | 145 | 14 | 0.45 |
TNF-α (pg/ml) | 12.8 | 9 | 5.7 | 2.5 | 0.029 |
MIF (pg/ml) | 1315 | 192 | 1179 | 264 | 0.34 |
IL-6 (pg/ml) | 18 | 1.9 | 18.4 | 3 | 0.414 |
IL-1β (pg/ml) | 5.9 | 3 | 3 | 0.9 | 0.14 |
IL-8 (pg/ml) | 2.2 | 0.4 | 2.5 | 0.47 | 0.843 |