Author and publication year | Study design | Sample size (n) | Age (years) | Administration mode | Follow-up period | Ascertainment of asthma | Outcomes | Endpoint measure | |
---|---|---|---|---|---|---|---|---|---|
Specific | Combined | ||||||||
Wells et al., 2012 [22] | RC | 1,828 | 12-56 | Single inhaler | *2.1(2.0) years | Asthma treatment | ------- | 1- Asthma-related hospitalization OR asthma-related ED visit OR Systemic Corticosteroid use | aHR |
Jacobs et al., 2012 [23] | C-C | 181 | 4-18 | Not stated | NA | Clinical diagnosis | 1- ICU admission | ------- | aOR OR |
2- Deaths | |||||||||
3- Intubation | |||||||||
4- Positive air pressure use | |||||||||
Stanford et al., 2012 [24] | RC | 10,837 | 65-79 | Single inhaler | 12 months | Claims for asthma | 1- Asthma-related hospitalization | 1- Asthma-related hospitalization OR asthma-related ED visits | aHR |
2- Asthma-related ED visits | |||||||||
3- Systemic Corticosteroid use | |||||||||
Guo et al., 2011 [21] | RC | 514,216 | 0-40 | Single & Separate inhalers | - | Claims for asthma | ------- | 1- Asthma-related hospitalization OR asthma-related ED visits OR Asthma-related intubations | aHR |
Stanford et al., 2010 [25] | RC | 50,428 | > 4 | Single inhaler | *290.4 (102.8) days | Claims for asthma | 1- Asthma-related hospitalization | 1- Asthma-related hospitalization OR asthma-related ED visits | aHR |
2- Asthma-related ED visits | |||||||||
Hagiwara et al., 2010 [26] | RC | 894 | 12-64 | Single inhaler | 3-12 months | Claims for asthma | 1-Asthma-related hospitalization | 1- Hospitalization OR ED visits | aOR |
2-Asthma-related ED visits | 2- Hospitalization OR ED visits OR Systemic Corticosteroid use | ||||||||
3-Use of SABAs | |||||||||
Delea et al., 2010 [27] | RC | 1,744 | > 12 | Single inhaler | 3-12 months | Claims for asthma | 1- ED visits | 1- ED visits OR Hospitalization | aOR |
2- ED visits OR hospitalization OR Systemic Corticosteroid use | |||||||||
de Vries et al., 2010 [28] | RC | 467,639 | >18 | Not stated | 5 years | Claims for asthma | 1- All mortality; | ------- | aRR |
2- Asthma-related mortality | |||||||||
3-Asthma-related hospitalization | |||||||||
4-GP visits for exacerbation | |||||||||
Lee et al., 2010 [29] | RC | 28,074 | 18-56 | Single & Separate inhalers | 12 months | Claims for asthma | 1- Asthma-related hospitalization | ------- | OR |
2-Asthma-related ED visits | |||||||||
3-Systemic Corticosteroid use | |||||||||
4- SABAs use | |||||||||
Thomas et al., 2009 [30] | RC | 64,348 | 10-58 | Single & Separate inhalers | 12 months | Claims for asthma and asthma treatment | 1- Respiratory Hospitalization | 1- Asthma-related hospitalization OR asthma-related ED visits OR > 2 prescription of Systemic Corticosteroid uses OR SABA prescription | aOR |
2- Systemic Corticosteroid use | |||||||||
3- SABAs use | |||||||||
Stanford et al., 2008 [31] | RC | 58,270 | > 12 | Single inhaler | 12 months | Claim for asthma | 1-Asthma-related Hospitalization | 1- Asthma-related ED visits OR asthma-related Hospitalization | aOR |
2- Asthma-related ED visits | aHR | ||||||||
Campbell et al., 2008 [32] | PC | 684 | > 18 | Single inhaler | 24 months | Severe asthma | ------- | 1- Asthma-related hospitalization OR asthma-related ED visit OR Systemic Corticosteroid use | aOR OR |
Colice et al., 2008 [33] | RC | 1,283 | 6-64 | Not stated | 12 months | Claims for asthma | 1- Asthma-related hospitalization | ------- | OR |
2- Asthma-related ED visits | |||||||||
Delea et al., 2008 [34] | RC | 2,269 | > 5 | Single & Separate inhalers | 12 months | Claims for asthma | 1- Asthma-related hospitalization | 1- Asthma-related hospitalization OR ED visits OR Systemic Corticosteroid use OR alternative study medication | aOR |
2- Asthma-related ED visits | 2- Asthma-related hospitalizations OR ED visits OR oral corticosteroid | ||||||||
3- Oral corticosteroids use | 3- Asthma-related hospitalization OR ED visits hospitalization | ||||||||
Friedman et al., 2007 [35] | RC | 5,503 | 12-65 | Single inhaler | 12 months | Claims for asthma | 1-Asthma-related hospitalization | ------- | aOR |
2-Asthma-related ED visits | |||||||||
3- Any ED visits | |||||||||
Zhang et al., 2007 [36] | RC | 2,596 | 15-55 | Single & Separate inhalers | 12 months | Claims for asthma | 1- Oral corticosteroid use | 1- Asthma-related hospitalization OR asthma-related ED visits | OR |
2- SABA use | |||||||||
Stempel et al., 2006 [37] | RC | 9,192 | 4-17 | Single inhaler | 12 months | Claims for asthma | 1- SABA use | 1- Asthma-related hospitalization OR asthma-related ED visit | aRR |
2-Corticosteroids use | |||||||||
O’Connor et al., 2005 [38] | RC | 2,414 | > 15 | Single & Separate inhalers | 12 months | Claims for asthma | ------- | 1- Asthma-related hospitalization OR ED visits | aOR aHR |
Nguyen et al., 2005 [20] | B-A | 50 | 4-17 | Single inhaler | 12 months | Enrolled patients | 1- Asthma-related hospitalization | ------- | aRR |
2- Asthma-related ED visits |