FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure

Respiratory Research

Table 1 Clinical characteristics of COPD and NS healthy women (control)

	Control n = 40	BE n = 40	TS n = 40	p
Characteristics
Age (years)	65 ± 10	72 ± 8^§	69 ± 9	0.01 vs Ctrl
Height (cm)	158 ± 6	147 ± 7^§	159 ± 10	0.01 vs TS
Height (cm)	158 ± 6	147 ± 7^§	159 ± 10	0.02 vs TS
Weight (Kg)	65.9 ± 9	62 ± 11	69 ± 9^§	0.05 vs Ctrl
BMI (Kg/m²)	27 ± 8	29 ± 5	26 ± 3^§	0.01 vs BE
Exposure and physiological characteristics
Tobacco index (Pack/yr)	-	-	50 ± 30
Biomass index (Hrs/year of exposure)	-	230 ± 132	-
FEV1 (% predicted)	107.8 ± 8.7	62.1 ± 25.6^§	49.5 ± 23.9^§	0.01 vs Ctrl
FEV1 (% predicted)	107.8 ± 8.7	62.1 ± 25.6^§	49.5 ± 23.9^§	0.03 BE vs TS
FVC (% predicted)	109 ± 9	78 ± 19^§	82 ± 14^§	0.01 vs Ctrl
FEV1/FVC ratio	91 ± 9.5	53 ± 16^§	56 ± 15^§	0.01 vs Ctrl
Bronchodilator response (FEV1; %)	-	9.54 ± 17	9.14 ± 8	0.883**
PaO₂ (mmHg)	-	53 ± 7	59 ± 10	0.056**
PaCO₂ (mmHg)	-	34 ± 4	32 ± 5	0.136**
6MWT (m)	-	274 ± 155	327 ± 142	0.075**
SaO₂ (%)	-	88 ± 5	91 ± 5	0.039**
Chronic respiratory questionnaire
Dyspnea	-	21 ± 10	17 ± 8	0.098**
Fatigue	-	19 ± 5	20 ± 5	0.711**
Master	-	37 ± 7	36 ± 9	0.570***
Control	-	22 ± 4	22 ± 5	0.988**
Total score	-	99 ± 15	95 ± 17	0.283**
GOLD stage
I	-	8 (20)	8 (20)	0.075*
II	-	25 (63)	15 (38)
III	-	6 (15)	12 (30)
IV	-	1 (2.)	5 (12)
Exacerbation rate/yr (min-max)	-	1.27 (1-3)	1.38 (1-3)	0.495**

Data are presented as mean ± SD unless otherwise indicated. Ctrl = Control; BE = biomass exposure; TS: tobacco smoking; BMI: biomass mass index; FEV₁: forced expiratory volume in one second; FVC: forced vital capacity;% predicted: percentage of the predicted value. For GOLD stage figures are presented as number (%).
Statistical tests: ^§ANOVA-Tukey test; *X² test; **Student-T test; ***Welch test. All comparisons with Ctrl and TS were against BE after Bonferroni adjustments.

ISSN: 1465-993X