Skip to main content

Table 1 Characteristics of subjects in monocyte-derived macrophage study

From: Impaired macrophage phagocytosis of bacteria in severe asthma

 

Normal

Non-severe asthma

Severe asthma

Number

14

14

14

Sex (F:M)

6:8

8:6

9:5

Age (years)

39.6 ± 2.7

45.9 ± 3.6

48.6 ± 2.9

Atopy#

2/14

10/14

14/14

Duration of asthma (years)

0

33.1 ± 4.0

37.9 ± 4.6

Exacerbations in past year

0

1.57 ± 0.48

3.78 ± 0.26***

FEV1 (% predicted)

98.31 ± 3.28

83.40 ± 3.41

68.24 ± 4.29**

FVC (% predicted)

97.00 ± 3.16

95.51 ± 3.70

81.99 ± 2.65**

Oral prednisolone (mg/d)

0

0

14.50 ± 3.0*** (n = 10)

Inhaled cortico-steroid, BDP equivalent (μg/day)

0

971 ± 203 (n = 11)

2257 ± 321** (n = 14)

  1. Abbreviations: BDP Beclomethasone dipropionate, FEV 1 forced expiratory volume in 1 sec, F Female, FVC forced vital capacity, M Male.
  2. #Atopy defined as positive skin prick test to one or more aeroallergens.
  3. Data shown as mean ± SEM. **p < 0.01, ***p < 0.001 compared to non-severe asthma.