From: Impaired macrophage phagocytosis of bacteria in severe asthma
 | Normal | Non-severe asthma | Severe asthma |
---|---|---|---|
Number | 14 | 14 | 14 |
Sex (F:M) | 6:8 | 8:6 | 9:5 |
Age (years) | 39.6 ± 2.7 | 45.9 ± 3.6 | 48.6 ± 2.9 |
Atopy# | 2/14 | 10/14 | 14/14 |
Duration of asthma (years) | 0 | 33.1 ± 4.0 | 37.9 ± 4.6 |
Exacerbations in past year | 0 | 1.57 ± 0.48 | 3.78 ± 0.26*** |
FEV1 (% predicted) | 98.31 ± 3.28 | 83.40 ± 3.41 | 68.24 ± 4.29** |
FVC (% predicted) | 97.00 ± 3.16 | 95.51 ± 3.70 | 81.99 ± 2.65** |
Oral prednisolone (mg/d) | 0 | 0 | 14.50 ± 3.0*** (n = 10) |
Inhaled cortico-steroid, BDP equivalent (μg/day) | 0 | 971 ± 203 (n = 11) | 2257 ± 321** (n = 14) |