Figure 9
From: Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis
Rac2 deficiency and BLM-induced fibrosis . (A) Representative images of Masson’s trichrome staining of lung sections 21 days after intratracheal saline or bleomycin administration to WT and rac2-/- mice (in every condition 5–8 mice were analyzed by histology). (B) Quantitation of lung fibrosis using Ashcroft’s criteria (5–8 mice were analyzed per group). Total collagen (C) and hydroxyproline content (D) of lungs 21 days were determined after intratracheal saline or bleomycin administration to WT and rac2-/- mice (n.s. not significant, *p < 0.05, n = 5-8).