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Table 1 Subject characteristics

From: Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions

  Healthy controls Controlled asthma Uncontrolled asthma
Subjects, n 8 9 16
Gender, men/women 3/5 6/3 10/6
Age, years 23 [22–28] 29 [25–35] 44 [28–52]
FEV1, (L) 3.7 [3.4–5.1] 4.0 [3.3–4.8] 3.0 [2.4–4.0]
FEV1, % of predicted 98 [91–113] 91 [86–103] 81 [72–88]
PD20, (μg) > 2000 296 [74–1143] 266 [96–531]
FeNO50, (ppb) 15 [9–17] 24 [17–36] 28 [20–48]
Bronchial NO, (ppb) 0.75 [0.45–0.98] 1.2 [0.9–1.6] 1.4 [0.85–2.7]
Alveolar NO, (ppb) 2.1 [2–2.5] 2.7 [1.7–3.4] 2.7 [1.8–3.5]
Atopy, yes/no 0/8 9/0 16/ 0
Rhinitis, yes/no 0/8 9/0 15/ 1
ICS/day, (μg) - 800 [400–800] 800 [400–800]
Smoking, yes/no 0/8 0/9 0/16
ACT score - 23 [22–24] 17 [13–19]
  1. FEV 1 = forced expiratory volume in 1 second, PD 20 = provocative dose (methacholine) producing a fall in FEV1 of 20 %, FeNO 50 = exhaled nitric oxide, measured at a flow rate of 50 ml ⁄ s, NO = nitric oxide, ppb = parts per billion, ICS = inhaled glucocorticosteroids, ACT = asthma control test.