Effects on exacerbations last (years) | Time horizon (years) | Hospital-treated exacerbations | ||
---|---|---|---|---|
Usual care | PHARMACOP | Prevented | ||
Basecase scenario (effects last for 3Â months) | ||||
0.25 | 1 | 0.24 | 0.18 | 0.07 |
Different time horizon | ||||
0.25 | 0.25 | 0.10 | 0.02 | 0.07 |
0.25 | 0.5 | 0.14 | 0.07 | 0.07 |
0.25 | 2 | 0.42 | 0.35 | 0.07 |
0.25 | 5 | 0.93 | 0.86 | 0.07 |
0.25 | 10 | 1.60 | 1.53 | 0.07 |
0.25 | 12.5 | 1.82 | 1.75 | 0.07 |
Different program run time (effects linear extrapolated) | ||||
1 | 1 | 0.24 | 0.06 | 0.18 |
5 | 5 | 0.93 | 0.23 | 0.70 |
12.5 | 12.5 | 1.82 | 0.46 | 1.36 |
Effect of adherence improvement lasts 2Â years | ||||
0.25 | 5 | 0.93 | 0.86 | 0.07 |
Effect of adherence improvement lasts 12.5Â years | ||||
0.25 | 12.5 | 1.82 | 1.75 | 0.07 |
Mean FEV 1 % pred of 40 | ||||
0.25 | 1 | 0.25 | 0.18 | 0.07 |
0.25 | 5 | 1.02 | 0.95 | 0.07 |
0.25 | 10 | 1.75 | 1.68 | 0.07 |
Mean FEV 1 % pred of 60 | ||||
0.25 | 1 | 0.22 | 0.15 | 0.07 |
0.25 | 5 | 0.84 | 0.77 | 0.07 |
0.25 | 10 | 1.44 | 1.37 | 0.07 |
Lower 95% CI RR effect on hospital treated exacerbations (RR = 0.121) | ||||
0.25 | 1 | 0.24 | 0.15 | 0.08 |
Upper 95% CI RR effect on hospital treated exacerbations (RR = 0.523) | ||||
0.25 | 1 | 0.24 | 0.19 | 0.05 |